Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione...
Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo
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Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
High concentrations of antioxidants in cancer cells are huge obstacle in cancer radiotherapy. Erastin was first discovered as an inducer of iron-dependent cell death called ferroptosis accompanied by antioxidant depletion caused by cystine glutamate antiporter inhibition. Therefore, treatment with erastin is expected to potentially enhance cellular...
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Full title
Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo
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TN_cdi_plos_journals_2321622815
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2321622815
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0225931
