Subtle changes in striatal muscarinic M1 and M4 receptor expression in the DYT1 knock-in mouse model...
Subtle changes in striatal muscarinic M1 and M4 receptor expression in the DYT1 knock-in mouse model of dystonia
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United States: Public Library of Science
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English
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United States: Public Library of Science
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In early-onset generalized torsion dystonia, caused by a GAG deletion in TOR1A (DYT1), enhanced striatal cholinergic activity has been suggested to be critically involved. Previous studies have shown increased acetylcholine levels in the striatum of DYT1 knock-in (KI) mice. Ex vivo data indicated that muscarinic receptor antagonists normalize the a...
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Full title
Subtle changes in striatal muscarinic M1 and M4 receptor expression in the DYT1 knock-in mouse model of dystonia
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TN_cdi_plos_journals_2322136776
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2322136776
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0226080
