14-3-3 scaffold proteins mediate the inactivation of trim25 and inhibition of the type I interferon...
14-3-3 scaffold proteins mediate the inactivation of trim25 and inhibition of the type I interferon response by herpesvirus deconjugases
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. Here, we report that the ubiquitin deconjugase (DUB) encoded in the N-terminus of the Epstein-Barr vir...
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Full title
14-3-3 scaffold proteins mediate the inactivation of trim25 and inhibition of the type I interferon response by herpesvirus deconjugases
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TN_cdi_plos_journals_2327518641
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2327518641
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1008146
