α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pa...
α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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The production of reactive oxygen species (ROS) by cisplatin is one of the major mechanisms of cisplatin-induced cytotoxicity. We examined the preventive effect of α-lipoic acid (LA) on cisplatin-induced toxicity via its antioxidant effects on in vitro and ex vivo culture systems. To elucidate the mechanism of the antioxidant activity of LA, NRF2 w...
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α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway
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TN_cdi_plos_journals_2330775343
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2330775343
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0226769
