Tankyrase inhibition sensitizes cells to CDK4 blockade
Tankyrase inhibition sensitizes cells to CDK4 blockade
About this item
Full title
Author / Creator
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Tankyrase (TNKS) 1/2 are positive regulators of WNT signaling by controlling the activity of the ß-catenin destruction complex. TNKS inhibitors provide an opportunity to suppress hyperactive WNT signaling in tumors, however, they have shown limited anti-proliferative activity as a monotherapy in human cancer cell lines. Here we perform a kinome-foc...
Alternative Titles
Full title
Tankyrase inhibition sensitizes cells to CDK4 blockade
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2331627980
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2331627980
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0226645
