Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagoni...
Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Accumulation of lipofuscin bisretinoids in the retina contributes to pathogenesis of macular degeneration. Retinol-Binding Protein 4 (RBP4) antagonists reduce serum retinol concentrations thus partially reducing retinol delivery to the retina which decreases bisretinoid synthesis. BPN-14136 is a novel RBP4 antagonist with good in vitro potency and...
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Full title
Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey
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TN_cdi_plos_journals_2344548003
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2344548003
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0228291
