Yap suppresses T-cell function and infiltration in the tumor microenvironment
Yap suppresses T-cell function and infiltration in the tumor microenvironment
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
A major challenge for cancer immunotherapy is sustaining T-cell activation and recruitment in immunosuppressive solid tumors. Here, we report that the levels of the Hippo pathway effector Yes-associated protein (Yap) are sharply induced upon the activation of cluster of differentiation 4 (CD4)-positive and cluster of differentiation 8 (CD8)-positiv...
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Full title
Yap suppresses T-cell function and infiltration in the tumor microenvironment
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Record Identifier
TN_cdi_plos_journals_2356004197
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2356004197
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3000591
