Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner
Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Extrachromosomal DNA can integrate into the genome with no sequence specificity producing an insertional mutation. This process, which is referred to as random integration (RI), requires a double stranded break (DSB) in the genome. Inducing DSBs by various means, including ionizing radiation, increases the frequency of integration. Here we report t...
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Full title
Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner
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TN_cdi_plos_journals_2356015242
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2356015242
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1008550
