Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation
Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation
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Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Aortic valve disease is a complex process characterized by valve interstitial cell activation, disruption of the extracellular matrix culminating in valve mineralization occurring over many years. We explored the function of the retinoblastoma protein (pRb) in aortic valve disease, given its critical role in mesenchymal cell differentiation includi...
Alternative Titles
Full title
Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation
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TN_cdi_plos_journals_2390639781
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2390639781
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0190623
