Pathogen to commensal? Longitudinal within-host population dynamics, evolution, and adaptation durin...
Pathogen to commensal? Longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection
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Author / Creator
Pearson, Talima , Sahl, Jason W. , Hepp, Crystal M. , Handady, Karthik , Hornstra, Heidie , Vazquez, Adam J. , Settles, Erik , Mayo, Mark , Kaestli, Mirjam , Williamson, Charles H. D. , Price, Erin P. , Sarovich, Derek S. , Cook, James M. , Wolken, Spenser R. , Bowen, Richard A. , Tuanyok, Apichai , Foster, Jeffrey T. , Drees, Kevin P. , Kidd, Timothy J. , Bell, Scott C. , Currie, Bart J. and Keim, Paul
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Although acute melioidosis is the most common outcome of Burkholderia pseudomallei infection, we have documented a case, P314, where disease severity lessened with time, and the pathogen evolved towards a commensal relationship with the host. In the current study, we used whole-genome sequencing to monitor this long-term symbiotic relationship to b...
Alternative Titles
Full title
Pathogen to commensal? Longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection
Authors, Artists and Contributors
Author / Creator
Sahl, Jason W.
Hepp, Crystal M.
Handady, Karthik
Hornstra, Heidie
Vazquez, Adam J.
Settles, Erik
Mayo, Mark
Kaestli, Mirjam
Williamson, Charles H. D.
Price, Erin P.
Sarovich, Derek S.
Cook, James M.
Wolken, Spenser R.
Bowen, Richard A.
Tuanyok, Apichai
Foster, Jeffrey T.
Drees, Kevin P.
Kidd, Timothy J.
Bell, Scott C.
Currie, Bart J.
Keim, Paul
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2390750258
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2390750258
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1008298
