An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing,...
An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Agents that modulate pre-mRNA splicing are of interest in multiple therapeutic areas, including cancer. We report our recent screening results with the application of a cell-based Triple Exon Skipping Luciferase Reporter (TESLR) using a library that is composed of FDA approved drugs, clinical compounds, and mechanistically characterized tool compou...
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Full title
An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications
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TN_cdi_plos_journals_2407761496
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2407761496
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0233672
