Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas’ disease drug di...
Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas’ disease drug discovery
About this item
Full title
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Publisher
San Francisco: Public Library of Science
Journal title
Language
English
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Publisher
San Francisco: Public Library of Science
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Scope and Contents
Contents
New assay designs are needed to improve the predictive value of the Trypanosoma cruzi in vitro tests used as part of the Chagas' disease drug development pipeline. Here, we employed a green fluorescent protein (eGFP)-expressing parasite line and live high-content imaging to monitor the growth of T. cruzi amastigotes in mouse embryonic fibroblasts....
Alternative Titles
Full title
Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas’ disease drug discovery
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Record Identifier
TN_cdi_plos_journals_2434499725
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2434499725
Other Identifiers
ISSN
1935-2735,1935-2727
E-ISSN
1935-2735
DOI
10.1371/journal.pntd.0008487
