Aldh inhibitor restores auditory function in a mouse model of human deafness
Aldh inhibitor restores auditory function in a mouse model of human deafness
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Author / Creator
Zhu, Guang-Jie , Gong, Sihao , Ma, Deng-Bin , Tao, Tao , He, Wei-Qi , Zhang, Linqing , Wang, Fang , Qian, Xiao-Yun , Zhou, Han , Fan, Chi , Wang, Pei , Chen, Xin , Zhao, Wei , Sun, Jie , Chen, Huaqun , Wang, Ye , Gao, Xiang , Zuo, Jian , Zhu, Min-Sheng , Gao, Xia and Wan, Guoqiang
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Genetic hearing loss is a common health problem with no effective therapy currently available. DFNA15, caused by mutations of the transcription factor POU4F3, is one of the most common forms of autosomal dominant non-syndromic deafness. In this study, we established a novel mouse model of the human DFNA15 deafness, with a Pou4f3 gene mutation (Pou4...
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Full title
Aldh inhibitor restores auditory function in a mouse model of human deafness
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TN_cdi_plos_journals_2451547193
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2451547193
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1009040
