Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block
Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block
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Author / Creator
Tran, Phu N , Sheng, Jiansong , Randolph, Aaron L , Baron, Claudia Alvarez , Thiebaud, Nicolas , Ren, Ming , Wu, Min , Johannesen, Lars , Volpe, Donna A , Patel, Dakshesh , Blinova, Ksenia , Strauss, David G , Wu, Wendy W and Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and addiction. QTC prolongation that crosses the 10 msec threshold of regulatory concern was observed at a supratherapeutic dose in two thorough QT studies for the transdermal buprenorphine product BUTRANS®. Because QTC prolongation can be associated with Torsades de Poi...
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Full title
Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block
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Record Identifier
TN_cdi_plos_journals_2458316837
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2458316837
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0241362
