PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease i...
PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort
About this item
Full title
Author / Creator
Small, Aeron M. , Huffman, Jennifer E. , Klarin, Derek , Lynch, Julie A. , Assimes, Themistocles , DuVall, Scott , Sun, Yan V. , Shere, Labiba , Natarajan, Pradeep , Gaziano, Michael , Rader, Daniel J. , Wilson, Peter W. F. , Tsao, Philip S. , Chang, Kyong-Mi , Cho, Kelly , O’Donnell, Christopher J. , Casas, Juan P. , Damrauer, Scott M. , on behalf of the VA Million Veteran Program and VA Million Veteran Program
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Therapeutic inhibition of PCSK9 protects against coronary artery disease (CAD) and ischemic stroke (IS). The impact on other diseases remains less well characterized.
We created a genetic risk score (GRS) for PCSK9 using four single nucleotide polymorphisms (SNPs) at or near the PCSK9 locus known to impact lower LDL-Cholesterol (LDL-C): rs115836...
Alternative Titles
Full title
PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort
Authors, Artists and Contributors
Author / Creator
Huffman, Jennifer E.
Klarin, Derek
Lynch, Julie A.
Assimes, Themistocles
DuVall, Scott
Sun, Yan V.
Shere, Labiba
Natarajan, Pradeep
Gaziano, Michael
Rader, Daniel J.
Wilson, Peter W. F.
Tsao, Philip S.
Chang, Kyong-Mi
Cho, Kelly
O’Donnell, Christopher J.
Casas, Juan P.
Damrauer, Scott M.
on behalf of the VA Million Veteran Program
VA Million Veteran Program
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2458949585
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2458949585
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0239752
