Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its...
Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its N-terminal domain
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Lysosomal accumulation of cholesterol is a hallmark of Niemann Pick type C (NPC) disease caused by mutations primarily in the lysosomal membrane protein NPC1. NPC1 contains a transmembrane sterol-sensing domain (SSD), which is supposed to regulate protein activity upon cholesterol binding, but the mechanisms underlying this process are poorly under...
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Full title
Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its N-terminal domain
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TN_cdi_plos_journals_2460772657
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2460772657
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ISSN
1553-7358,1553-734X
E-ISSN
1553-7358
DOI
10.1371/journal.pcbi.1007554
