Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein
Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The HIV-1 envelope glycoprotein (Env) mediates viral entry via conformational changes associated with binding the cell surface receptor (CD4) and coreceptor (CCR5/CXCR4), resulting in subsequent fusion of the viral and cellular membranes. While the gp120 Env surface subunit has been extensively studied for its role in viral entry and evasion of the...
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Full title
Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein
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TN_cdi_plos_journals_2460980433
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2460980433
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1008577
