A multistationary loop model of ALS unveils critical molecular interactions involving mitochondria a...
A multistationary loop model of ALS unveils critical molecular interactions involving mitochondria and glucose metabolism
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Full title
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Amyotrophic lateral sclerosis (ALS) is a poor-prognosis disease with puzzling pathogenesis and inconclusive treatments. We develop a mathematical model of ALS based on a system of interactive feedback loops, focusing on the mutant SOD1
G93A
mouse. Misfolded mutant SOD1 aggregates in motor neuron (MN) mitochondria and triggers a first loop cha...
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Full title
A multistationary loop model of ALS unveils critical molecular interactions involving mitochondria and glucose metabolism
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TN_cdi_plos_journals_2470906852
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2470906852
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0244234
