LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient
LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Nucleocytoplasmic transport (NCT) defects have been implicated in neurodegenerative diseases such as
C9ORF72
-associated amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). Here, we identify a neuroprotective pathway of like-Sm protein 12 (
LSM12
) and exchange protein directly activated by cyclic AMP 1 (
EPAC1
Alternative Titles
Full title
LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient
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TN_cdi_plos_journals_2479140114
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2479140114
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3001002
