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Pharmacological upregulation of GLT-1 alleviates the cognitive impairments in the animal model of te...

Pharmacological upregulation of GLT-1 alleviates the cognitive impairments in the animal model of te...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2482650354

Pharmacological upregulation of GLT-1 alleviates the cognitive impairments in the animal model of temporal lobe epilepsy

About this item

Full title

Pharmacological upregulation of GLT-1 alleviates the cognitive impairments in the animal model of temporal lobe epilepsy

Publisher

United States: Public Library of Science

Journal title

PloS one, 2021-01, Vol.16 (1), p.e0246068-e0246068

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

It is known that hippocampal epileptogenesis is accompanied by hyperexcitability, glutamate-related neuronal dysfunctions and consequently cognitive deficits. However, the neuroprotective role of astrocytic glutamate uptake through the Glutamate Transporter-1 (GLT-1) remains to be unknown in these processes. Therefore, to assess the effect of gluta...

Alternative Titles

Full title

Pharmacological upregulation of GLT-1 alleviates the cognitive impairments in the animal model of temporal lobe epilepsy

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2482650354

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2482650354

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0246068

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