HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma
HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma
About this item
Full title
Author / Creator
Huang, Jiajun , Zhao, Xiaoyu , Li, Xiang , Peng, Jiwei , Yang, Weihao and Mi, Shengli
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Renal cell carcinoma (RCC) is responsible for most cases of the kidney cancer. Previous research showed that low serum levels of cholesterol level positively correlate with poorer RCC-specific survival outcomes. However, the underlying mechanisms and functional significance of the role of cholesterol in the development of RCC remain obscure. 3-Hydr...
Alternative Titles
Full title
HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma
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Author / Creator
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Record Identifier
TN_cdi_plos_journals_2528203279
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2528203279
Other Identifiers
ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3001197
