Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a co...
Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a concerted repacking of the protein core
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Critical molecular events that control conformational transitions in most allosteric proteins are ill-defined. The mannose-specific FimH protein of
Escherichia coli
is a prototypic bacterial adhesin that switches from an ‘inactive’ low-affinity state (LAS) to an ‘active’ high-affinity state (HAS) conformation allosterically upon mannose bindi...
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Full title
Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a concerted repacking of the protein core
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TN_cdi_plos_journals_2528219308
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2528219308
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1009440
