Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells
Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells
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San Francisco: Public Library of Science
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English
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San Francisco: Public Library of Science
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Clofarabine, an FDA approved purine analog, is used in the treatment of relapsed or refractory acute lymphoblastic leukemia. Clofarabine acts by inhibiting DNA synthesis. We demonstrated that clofarabine may have a novel function though inhibiting CD99, a transmembrane protein highly expressed on Ewing Sarcoma (ES) cells. CD99 is a validated target...
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Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells
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TN_cdi_plos_journals_2541759039
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2541759039
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0253170
