Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibil...
Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model
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Author / Creator
Lee, Leo Y , Zhou, Jie , Koszalka, Paulina , Frise, Rebecca , Farrukee, Rubaiyea , Baba, Keiko , Miah, Shahjahan , Shishido, Takao , Galiano, Monica , Hashimoto, Takashi , Omoto, Shinya , Uehara, Takeki , Mifsud, Edin J , Collinson, Neil , Kuhlbusch, Klaus , Clinch, Barry , Wildum, Steffen , Barclay, Wendy S and Hurt, Aeron C
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Baloxavir is approved in several countries for the treatment of uncomplicated influenza in otherwise-healthy and high-risk patients. Treatment-emergent viruses with reduced susceptibility to baloxavir have been detected in clinical trials, but the likelihood of widespread occurrence depends on replication capacity and onward transmission. We evalua...
Alternative Titles
Full title
Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model
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Record Identifier
TN_cdi_plos_journals_2541853663
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2541853663
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1009527
