Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provid...
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
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United States: Public Library of Science
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English
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United States: Public Library of Science
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G protein–coupled receptors (GPCRs) are critical regulators of cellular function acting via heterotrimeric G proteins as their primary transducers with individual GPCRs capable of pleiotropic coupling to multiple G proteins. Structural features governing G protein selectivity and promiscuity are currently unclear. Here, we used cryo-electron micros...
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Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
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TN_cdi_plos_journals_2552289217
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2552289217
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3001295
