α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfoldin...
α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The accumulation of α-synuclein (α-syn) aggregates in specific brain regions is a hallmark of synucleinopathies including Parkinson disease (PD). α-Syn aggregates propagate in a “prion-like” manner and can be transferred inside lysosomes to recipient cells through tunneling nanotubes (TNTs). However, how lysosomes participate in the spreading of α-...
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Full title
α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes
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TN_cdi_plos_journals_2561940255
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2561940255
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3001287
