A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host L...
A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Allosteric integrase inhibitors (ALLINIs) are a class of experimental anti-HIV agents that target the noncatalytic sites of the viral integrase (IN) and interfere with the IN-viral RNA interaction during viral maturation. Here, we report a highly potent and safe pyrrolopyridine-based ALLINI, STP0404, displaying picomolar IC
50
in human PBMCs...
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Full title
A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site
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TN_cdi_plos_journals_2561940895
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2561940895
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1009671
