Roadmap for the use of base editors to decipher drug mechanism of action
Roadmap for the use of base editors to decipher drug mechanism of action
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
CRISPR base editors are powerful tools for large-scale mutagenesis studies. This kind of approach can elucidate the mechanism of action of compounds, a key process in drug discovery. Here, we explore the utility of base editors in an early drug discovery context focusing on G-protein coupled receptors. A pooled mutagenesis screening framework was s...
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Full title
Roadmap for the use of base editors to decipher drug mechanism of action
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TN_cdi_plos_journals_2575052975
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2575052975
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0257537
