Global Rhes knockout in the Q175 Huntington’s disease mouse model
Global Rhes knockout in the Q175 Huntington’s disease mouse model
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Huntington’s disease (HD) results from an expansion mutation in the polyglutamine tract in huntingtin. Although huntingtin is ubiquitously expressed in the body, the striatum suffers the most severe pathology. Rhes is a Ras-related small GTP-binding protein highly expressed in the striatum that has been reported to modulate mTOR and sumoylation of...
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Full title
Global Rhes knockout in the Q175 Huntington’s disease mouse model
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TN_cdi_plos_journals_2582105931
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2582105931
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0258486
