Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse...
Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Perturbation of the excitation/inhibition (E/I) balance leads to neurodevelopmental diseases including to autism spectrum disorders, intellectual disability, and epilepsy. Loss-of-function mutations in the
DYRK1A
gene, located on human chromosome 21 (Hsa21,) lead to an intellectual disability syndrome associated with microcephaly, epilepsy, a...
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Full title
Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome
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TN_cdi_plos_journals_2582589608
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2582589608
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1009777
