Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset
Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset
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Publisher
San Francisco: Public Library of Science
Journal title
Language
English
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Publisher
San Francisco: Public Library of Science
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Contents
Kohlschütter-Tönz syndrome (KTS) manifests as neurological dysfunctions, including early-onset seizures. Mutations in the citrate transporter
SLC13A5
are associated with KTS, yet their underlying mechanisms remain elusive. Here, we report that a
Drosophila SLC13A5
homolog,
I’m not dead yet
(
Indy
), constitutes a neurometabo...
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Full title
Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset
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TN_cdi_plos_journals_2598100034
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2598100034
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1009871
