Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agoni...
Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agonist (GLA) to generate anti-tumor immunological memory
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Systemic interleukin-12 (IL12) anti-tumor therapy is highly potent but has had limited utility in the clinic due to severe toxicity. Here, we present two IL12-expressing vector platforms, both of which can overcome the deficiencies of previous systemic IL12 therapies: 1) an integrating lentiviral vector, and 2) a self-replicating messenger RNA form...
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Full title
Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agonist (GLA) to generate anti-tumor immunological memory
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TN_cdi_plos_journals_2605596785
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2605596785
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0259301
