Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans
Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans
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Author / Creator
Xie, Baocai , Shi, Xiaochen , Li, Yan , Xia, Bo , Zhou, Jia , Du, Minjie , Xing, Xiangyang , Bai, Liang , Liu, Enqi , Alvarez, Fernando , Jin, Long , Deng, Shaoping , Mitchell, Grant A. , Pan, Dengke , Li, Mingzhou and Wu, Jiangwei
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Genetic variants in the asialoglycoprotein receptor 1 (
ASGR1
) are associated with a reduced risk of cardiovascular disease (CVD) in humans. However, the underlying molecular mechanism remains elusive. Given the cardiovascular similarities between pigs and humans, we generated ASGR1-deficient pigs using the CRISPR/Cas9 system. These pigs sho...
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Full title
Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans
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TN_cdi_plos_journals_2610943670
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2610943670
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1009891
