Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer...
Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells
About this item
Full title
Author / Creator
Alaqbi, Saif Sattar , Burke, Lynsey , Guterman, Inna , Green, Caleb , West, Kevin , Palacios-Gallego, Raquel , Cai, Hong , Alexandrou, Constantinos , Myint, Ni Ni Moe , Parrott, Emma , Howells, Lynne M. , Higgins, Jennifer A. , Jones, Donald J. L. , Singh, Rajinder , Britton, Robert G. , Tufarelli, Cristina , Thomas, Anne and Rufini, Alessandro
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Research into the metabolism of the non-essential amino acid (NEAA) proline in cancer has gained traction in recent years. The last step in the proline biosynthesis pathway is catalyzed by pyrroline-5-carboxylate reductase (PYCR) enzymes. There are three PYCR enzymes: mitochondrial PYCR1 and 2 and cytosolic PYCR3 encoded by separate genes. The expr...
Alternative Titles
Full title
Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells
Authors, Artists and Contributors
Author / Creator
Burke, Lynsey
Guterman, Inna
Green, Caleb
West, Kevin
Palacios-Gallego, Raquel
Cai, Hong
Alexandrou, Constantinos
Myint, Ni Ni Moe
Parrott, Emma
Howells, Lynne M.
Higgins, Jennifer A.
Jones, Donald J. L.
Singh, Rajinder
Britton, Robert G.
Tufarelli, Cristina
Thomas, Anne
Rufini, Alessandro
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2626213866
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2626213866
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0262364
