Dissecting mutational allosteric effects in alkaline phosphatases associated with different Hypophos...
Dissecting mutational allosteric effects in alkaline phosphatases associated with different Hypophosphatasia phenotypes: An integrative computational investigation
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Author / Creator
Xiao, Fei , Zhou, Ziyun , Song, Xingyu , Gan, Mi , Long, Jie , Verkhivker, Gennady and Hu, Guang
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Contents
Hypophosphatasia (HPP) is a rare inherited disorder characterized by defective bone mineralization and is highly variable in its clinical phenotype. The disease occurs due to various loss-of-function mutations in ALPL, the gene encoding tissue-nonspecific alkaline phosphatase (TNSALP). In this work, a data-driven and biophysics-based approach is pr...
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Full title
Dissecting mutational allosteric effects in alkaline phosphatases associated with different Hypophosphatasia phenotypes: An integrative computational investigation
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TN_cdi_plos_journals_2651153383
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2651153383
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ISSN
1553-7358,1553-734X
E-ISSN
1553-7358
DOI
10.1371/journal.pcbi.1010009
