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The TSP-1 domain of the matricellular protein CCN5 is essential for its nuclear localization and ant...

The TSP-1 domain of the matricellular protein CCN5 is essential for its nuclear localization and ant...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2656181157

The TSP-1 domain of the matricellular protein CCN5 is essential for its nuclear localization and anti-fibrotic function

About this item

Full title

The TSP-1 domain of the matricellular protein CCN5 is essential for its nuclear localization and anti-fibrotic function

Publisher

United States: Public Library of Science

Journal title

PloS one, 2022-04, Vol.17 (4), p.e0267629-e0267629

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The matricellular protein CCN5 exerts anti-fibrotic activity in hearts partly by inducing reverse trans-differentiation of myofibroblasts (MyoFBs) to fibroblasts (FBs). CCN5 consists of three structural domains: an insulin-like growth factor binding protein (IGFBP), a von Willebrand factor type C (VWC), and a thrombospondin type 1 (TSP-1). In this...

Alternative Titles

Full title

The TSP-1 domain of the matricellular protein CCN5 is essential for its nuclear localization and anti-fibrotic function

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2656181157

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2656181157

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0267629

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