Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of...
Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk
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Author / Creator
Alzheimer’s Disease Neuroimaging Initiative (ADNI) , Dominantly Inherited Alzheimer Network (DIAN) , on behalf of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) , on behalf of the Dominantly Inherited Alzheimer Network (DIAN) , Ali, Muhammad , Sung, Yun Ju , Wang, Fengxian , Fernández, Maria V , Morris, John C , Fagan, Anne M , Blennow, Kaj , Zetterberg, Henrik , Heslegrave, Amanda , Johansson, Per M , Svensson, Johan , Nellgård, Bengt , Lleó, Alberto , Alcolea, Daniel , Clarimon, Jordi , Rami, Lorena , Molinuevo, José Luis , Suárez-Calvet, Marc , Morenas-Rodríguez, Estrella , Kleinberger, Gernot , Haass, Christian , Ewers, Michael , Levin, Johannes , Farlow, Martin R , Perrin, Richard J and Cruchaga, Carlos
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience during normal aging, were recently shown to be associated with Alzheimer disease (AD) risk in cognitively normal participants who are APOE ε4 carriers...
Alternative Titles
Full title
Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk
Authors, Artists and Contributors
Author / Creator
Dominantly Inherited Alzheimer Network (DIAN)
on behalf of the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
on behalf of the Dominantly Inherited Alzheimer Network (DIAN)
Ali, Muhammad
Sung, Yun Ju
Wang, Fengxian
Fernández, Maria V
Morris, John C
Fagan, Anne M
Blennow, Kaj
Zetterberg, Henrik
Heslegrave, Amanda
Johansson, Per M
Svensson, Johan
Nellgård, Bengt
Lleó, Alberto
Alcolea, Daniel
Clarimon, Jordi
Rami, Lorena
Molinuevo, José Luis
Suárez-Calvet, Marc
Morenas-Rodríguez, Estrella
Kleinberger, Gernot
Haass, Christian
Ewers, Michael
Levin, Johannes
Farlow, Martin R
Perrin, Richard J
Cruchaga, Carlos
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2686265922
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2686265922
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0267298
