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Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells

Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2686267079

Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells

About this item

Full title

Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells

Publisher

United States: Public Library of Science

Journal title

PloS one, 2022-05, Vol.17 (5), p.e0268635-e0268635

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Phenothiazines (PTZ) were developed as inhibitors of monoamine neurotransmitter receptors, notably dopamine receptors. Because of this activity they have been used for decades as antipsychotic drugs. In addition, they possess significant anti-cancer properties and several attempts for their repurposing were made. However, their incompletely underst...

Alternative Titles

Full title

Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2686267079

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2686267079

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0268635

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