Sex-, age-, and organ-dependent improvement of bile acid hydrophobicity by ursodeoxycholic acid trea...
Sex-, age-, and organ-dependent improvement of bile acid hydrophobicity by ursodeoxycholic acid treatment: A study using a mouse model with human-like bile acid composition
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Publisher
San Francisco: Public Library of Science
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Language
English
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San Francisco: Public Library of Science
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Contents
Cyp2a12.sup.-/- Cyp2c70.sup.-/- double knockout (DKO) mice have a human-like hydrophobic bile acid (BA) composition and show reduced fertility and liver injury. Ursodeoxycholic acid (UDCA) is a hydrophilic and cytoprotective BA used to treat various liver injuries in humans. This study investigated the effects of orally administered UDCA on fertili...
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Full title
Sex-, age-, and organ-dependent improvement of bile acid hydrophobicity by ursodeoxycholic acid treatment: A study using a mouse model with human-like bile acid composition
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TN_cdi_plos_journals_2688481363
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2688481363
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0271308
