TNFα-induced metabolic reprogramming drives an intrinsic anti-viral state
TNFα-induced metabolic reprogramming drives an intrinsic anti-viral state
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Cytokines induce an anti-viral state, yet many of the functional determinants responsible for limiting viral infection are poorly understood. Here, we find that TNFα induces significant metabolic remodeling that is critical for its anti-viral activity. Our data demonstrate that TNFα activates glycolysis through the induction of hexokinase 2 (HK2),...
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Full title
TNFα-induced metabolic reprogramming drives an intrinsic anti-viral state
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TN_cdi_plos_journals_2703164466
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2703164466
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1010722
