Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence div...
Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
A growing body of theoretical and experimental evidence suggests that intramolecular epistasis is a major determinant of rates and patterns of protein evolution and imposes a substantial constraint on the evolution of novel protein functions. Here, we examine the role of intramolecular epistasis in the recurrent evolution of resistance to cardioton...
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Full title
Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence
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TN_cdi_plos_journals_2715132115
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2715132115
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1010323
