Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazol...
Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway
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Full title
Author / Creator
Publisher
San Francisco: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
San Francisco: Public Library of Science
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Scope and Contents
Contents
We report herein, the design and synthesis of thiazolidine-2,4-diones derivatives as new inhibitors for VEGFR-2. The designed members were assessed for their
in vitro
anticancer activity against four cancer cell lines; A549, Caco-2, HepG-2 and MDA-MB-231. Compound
14a
showed the most potent effects against Caco-2, and HepG-2 cell lines...
Alternative Titles
Full title
Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway
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Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2717290495
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2717290495
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0272362
