A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress
A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Partial loss-of-function mutations in glycosylation pathways underlie a set of rare diseases called Congenital Disorders of Glycosylation (CDGs). In particular, DPAGT1-CDG is caused by mutations in the gene encoding the first step in N-glycosylation,
DPAGT1
, and this disorder currently lacks effective therapies. To identify potential therape...
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Full title
A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress
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TN_cdi_plos_journals_2725272816
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2725272816
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1010430
