Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites
Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites
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Author / Creator
Russell, Timothy James , De Silva, Erandi K. , Crowley, Valerie M. , Shaw-Saliba, Kathryn , Dube, Namita , Josling, Gabrielle , Pasaje, Charisse Flerida A. , Kouskoumvekaki, Irene , Panagiotou, Gianni , Niles, Jacquin C. , Jacobs-Lorena, Marcelo , Denise Okafor, C. , Gamo, Francisco-Javier and Llinás, Manuel
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Plasmodium
parasites are reliant on the Apicomplexan AP2 (ApiAP2) transcription factor family to regulate gene expression programs. AP2 DNA binding domains have no homologs in the human or mosquito host genomes, making them potential antimalarial drug targets. Using an
in-silico
screen to dock thousands of small molecules into the crystal...
Alternative Titles
Full title
Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites
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TN_cdi_plos_journals_2737136231
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2737136231
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1010887
