Identification of SaCas9 orthologs containing a conserved serine residue that determines simple NNGG...
Identification of SaCas9 orthologs containing a conserved serine residue that determines simple NNGG PAM recognition
About this item
Full title
Author / Creator
Wang, Shuai , Tao, Chen , Mao, Huilin , Hou, Linghui , Wang, Yao , Qi, Tao , Yang, Yuan , Ong, Sang-Ging , Hu, Shijun , Chai, Renjie and Wang, Yongming
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Due to different nucleotide preferences at target sites, no single Cas9 is capable of editing all sequences. Thus, this highlights the need to establish a Cas9 repertoire covering all sequences for efficient genome editing. Cas9s with simple protospacer adjacent motif (PAM) requirements are particularly attractive to allow for a wide range of genom...
Alternative Titles
Full title
Identification of SaCas9 orthologs containing a conserved serine residue that determines simple NNGG PAM recognition
Authors, Artists and Contributors
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Record Identifier
TN_cdi_plos_journals_2755149345
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2755149345
Other Identifiers
ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3001897
