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wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyot...

wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyot...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2755155710

wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome

About this item

Full title

wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome

Publisher

United States: Public Library of Science

Journal title

PLoS genetics, 2022-11, Vol.18 (11), p.e1010496-e1010496

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Bone and muscle are coupled through developmental, mechanical, paracrine, and autocrine signals. Genetic variants at the CPED1-WNT16 locus are dually associated with bone- and muscle-related traits. While Wnt16 is necessary for bone mass and strength, this fails to explain pleiotropy at this locus. Here, we show wnt16 is required for spine and musc...

Alternative Titles

Full title

wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_2755155710

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2755155710

Other Identifiers

ISSN

1553-7404,1553-7390

E-ISSN

1553-7404

DOI

10.1371/journal.pgen.1010496

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