The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcript...
The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription
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Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Activation of the NF-κB signaling pathway by Protein Kinase C (PKC) agonists is a potent mechanism for human immunodeficiency virus (HIV) latency disruption
in vitro
. However, significant toxicity risks and the lack of evidence supporting their activity
in vivo
have limited further evaluation of PKC agonists as HIV latency-reversing ag...
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Full title
The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription
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TN_cdi_plos_journals_2762198722
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2762198722
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1010245
