Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p...
Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p62-mediated macroautophagy
About this item
Full title
Author / Creator
Lin, Jiacheng , Yin, Limin , Xu, Xia-Zhen , Sun, He-Chen , Huang, Zhi-Hua , Ni, Xue-Yun , Chen, Yan and Lin, Xu
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
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Scope and Contents
Contents
The hepatitis B virus (HBV) core protein (HBc) functions in multiple steps of the viral life cycle. Heteroaryldihydropyrimidine compounds (HAPs) such as Bay41-4109 are capsid protein allosteric modulators that accelerate HBc degradation and inhibit the virion secretion of HBV, specifically by misleading HBc assembly into aberrant non-capsid polymer...
Alternative Titles
Full title
Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p62-mediated macroautophagy
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_plos_journals_2762201591
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2762201591
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1010204
