Small-molecule inhibitors of proteasome increase CjCas9 protein stability
Small-molecule inhibitors of proteasome increase CjCas9 protein stability
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Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The small size of CjCas9 can make easier its vectorization for
in vivo
gene therapy. However, compared to the SpCas9, the CjCas9 is, in general, less efficient to generate indels in target genes. The factors that affect its efficacity are not yet determined. We observed that the CjCas9 protein expressed in HEK293T cells after transfection of...
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Full title
Small-molecule inhibitors of proteasome increase CjCas9 protein stability
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TN_cdi_plos_journals_2767165520
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2767165520
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0280353
