Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex f...
Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Cas12a is a programmable nuclease for adaptive immunity against invading nucleic acids in CRISPR–Cas systems. Here, we report the crystal structures of apo Cas12a from
Lachnospiraceae bacterium MA2020 (Lb2)
and the
Lb2
Cas12a+crRNA complex, as well as the cryo-EM structure and functional studies of the
Lb2
Cas12a+crRNA+DNA complex...
Alternative Titles
Full title
Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage
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Record Identifier
TN_cdi_plos_journals_2802052930
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_2802052930
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3002023
